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Article

The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.

The Journal of clinical investigation - 1 Nov 1996

Gagnon J, Mauriège P, Roy S, Sjöström D, Chagnon Y C, Dionne F T, Oppert J M, Pérusse L, Sjöström L, Bouchard C

Abstract excerpt

The beta adrenergic system plays a key role in regulating energy balance through the stimulation of both thermogenesis and lipid mobilization in brown and white adipose tissues in human and various animal models. Recent studies have suggested that a missense Trp64Arg mutation in the beta3 adrener...

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Identifiers

PMID: 8903328
DOI: 10.1172/JCI119014
PMCID: PMC507653

Genes

ADRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8903328-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.PMID 8903328Read ↗

No effect of Trp64Arg beta3-adrenoceptor polymorphism on the plasma leptin concentration in Pima Indians.Semantic proximity Read ↗

The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: a longitudinal analysis.Semantic proximity Read ↗

Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with body mass index.Semantic proximity Read ↗

W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample.Semantic proximity Read ↗

Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity.Semantic proximity Read ↗

The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.Semantic proximity Read ↗

Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.Semantic proximity Read ↗

The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.Semantic proximity Read ↗

beta3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea.Semantic proximity Read ↗

A Trp 64 Arg mutation in the beta3-adrenergic receptor gene is not associated with moderate overweight in Japanese workers.Semantic proximity Read ↗

TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.Semantic proximity Read ↗

Comparison of body fat distribution and blood lipid profiles according to Trp64Arg polymorphism for the beta 3-adrenergic receptor gene in Korean middle-aged women.Semantic proximity Read ↗

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