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Article

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.

The Journal of clinical investigation - 1 Jul 2000

Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P

Abstract excerpt

By integrating an agonist satiety signal, provided by alpha-melanocyte-stimulating hormone (alpha-MSH), and an antagonist signal, provided by agouti-related protein (AGRP), the melanocortin-4 receptor (MC4-R) is a key element in the hypothalamic control of food intake. Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice. In humans, frameshift mutations in MC4-R cause an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

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Identifiers

PMID: 10903341
DOI: 10.1172/JCI9238
PMCID: PMC314306

Genes

AGRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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