Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.

The Journal of biological chemistry - 20 Jun 2003

Nijenhuis Wouter A J, Garner Keith M, van Rozen Rea J, Adan Roger A H

Abstract excerpt

The melanocortin-4 receptor (MC4R) plays an important role in the regulation of body weight in rodents. Mutations in the coding region of the MC4R are found more frequently in obese individuals, supporting the hypothesis that also in humans deficient melanocortin signaling may lead to obesity. Fa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Receptor, Melanocortin, Type 4
Share to Amino Acid Substitution
Share to Body Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Codon, Nonsense

Share to Frameshift Mutation

Share to Mutation, Missense

Share to Obesity

Share to Receptors, Corticotropin

Source

Identifiers

PMID: 12690102
DOI: 10.1074/jbc.M211326200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12690102-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.PMID 12690102Read ↗

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.Semantic proximity Read ↗

Mutations in melanocortin-4 receptor and human obesity.Semantic proximity Read ↗

Obesity-associated mutations in the human melanocortin-4 receptor gene.Semantic proximity Read ↗

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity.Semantic proximity Read ↗

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.Semantic proximity Read ↗

Molecular genetics of human obesity-associated MC4R mutations.Semantic proximity Read ↗

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.Semantic proximity Read ↗

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.Semantic proximity Read ↗

Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.Semantic proximity Read ↗

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.Semantic proximity Read ↗

Melanocortin 4 receptor mutation in obesitySemantic proximity Read ↗

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.