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Article

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.

The Journal of biological chemistry - 20 Jun 2003

Nijenhuis Wouter A J, Garner Keith M, van Rozen Rea J, Adan Roger A H

Abstract excerpt

The melanocortin-4 receptor (MC4R) plays an important role in the regulation of body weight in rodents. Mutations in the coding region of the MC4R are found more frequently in obese individuals, supporting the hypothesis that also in humans deficient melanocortin signaling may lead to obesity. Family studies that were carried out to demonstrate the relevance of single mutations for obesity were mostly...

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Source

Identifiers

PMID: 12690102
DOI: 10.1074/jbc.M211326200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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