Article
Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain.
Virology - 10 Apr 2004
Grebennikova T V, Clouser D F, Vorwald A C, Musienko M I, Mengeling W L, Lager K M, Wesley R D, Biketov S F, Zaberezhny A D, Aliper T I, Nepoklonov E A
Abstract excerpt
Pigs were exposed to three passages of the NADC-8 strain of porcine reproductive and respiratory syndrome virus (PRRSV) to investigate the relationship between genotypic and phenotypic properties. Differences were found in the virulence of the three passages called virulent, intermediate, and avirulent. Avirulent virus was derived by attenuation of virulent virus in cell culture and intermediate virus was derived...
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