Article
Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains.
Virus research - 5 Nov 2001
Yuan S, Mickelson D, Murtaugh M P, Faaberg K S
Abstract excerpt
Two full-length porcine reproductive and respiratory syndrome virus (PRRSV) genomes, strain VR-2332 and its cell culture passaged descendent RespPRRS vaccine strain, were compared and analyzed in order to identify possible sites of attenuation. Of the 41 nucleotide changes, 12 resulted in conservative changes and 18 produced non-conservative changes. The results suggest that key amino acids in ORF1 may contribute...
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