Article
Molecular mutations associated with the in vitro passage of virulent porcine reproductive and respiratory syndrome virus.
Virus genes - 1 Apr 2009
Han Wei, Wu Jia-Jun, Deng Xiao-Yu, Cao Zhen, Yu Xiu-Ling, Wang Chuan-Bin, Zhao Tie-Zhu, Chen Nan-Hua, Hu Hong-Hui, Bin Wang, Hou Li-Li, Wang Li-Lin, Tian Ke-Gong, Zhang Zhong-Qiu
Abstract excerpt
Mutants of a highly pathogenic, porcine reproductive, and respiratory syndrome virus (PRRSV), JXA1 strain, were prepared by continuous in vitro passage. Genomic sequence comparisons were made between mutants obtained at different passages and the parental strain JXA1. The mutant strain obtained at passage 80 contained a 12 nucleotide insertion and 108 nucleotide mutations that resulted in 45 amino acid changes....
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