Article
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.
Clinical microbiology reviews - 1 Apr 2006
Piddock Laura J V
Abstract excerpt
Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-resistant bacteria. Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug (antibiotic) resistance (MDR). However, the clinical relevance of efflux-mediated resistance is species, drug,...
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