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Article

Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes.

Biochemical Society transactions - 1 Apr 2004

Fruman D A

Abstract excerpt

The PI3K (phosphoinositide 3-kinase) signalling pathway promotes proliferation and transformation in many cell types. This is particularly well illustrated by studies of primary lymphocytes and their leukaemic counterparts. PI3K activation is required for proliferation of T cells and B cells, and certain oncogenes cause leukaemia in part by promoting PI3K signalling. Genetic manipulation of this pathway, together...

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Identifiers

PMID: 15046598
DOI: 10.1042/bst0320315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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