Article
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010
Foukas Lazaros C, Berenjeno Inma M, Gray Alexander, Khwaja Asim, Vanhaesebroeck Bart
Abstract excerpt
Small molecule inhibitors of PI3K for oncology mainly target the class I PI3Ks, comprising the p110alpha, beta, gamma, and delta isoforms, of which only p110alpha is mutated in cancer. To assess the roles of class I PI3K isoforms in cell proliferation and survival, we generated immortalized mouse leukocyte and fibroblast models in which class I PI3Ks were inactivated by genetic and pharmacological approaches. In...
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