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Article

The emerging mechanisms of isoform-specific PI3K signalling.

Nature reviews. Molecular cell biology - 1 May 2010

Vanhaesebroeck Bart, Guillermet-Guibert Julie, Graupera Mariona, Bilanges Benoit

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological functions. A further level of complexity derives from the existence of eight PI3K isoforms, which are divided into class I, class II and class III PI3Ks. PI3K signalling has been implicated in metabolic control, immunity, angiogenesis and cardiovascular homeostasis, and is one of the most...

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PMID: 20379207
DOI: 10.1038/nrm2882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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