Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery.

Expert opinion on therapeutic targets - 1 Feb 2008

Maira Sauveur-Michel, Voliva Charles, Garcia-Echeverria Carlos

Abstract excerpt

BACKGROUND: A substantial number of epidemiologic and experimental studies support an important role for Class I phosphatidylinositol 3-kinases (PI3Ks) in the biology of human cancer. OBJECTIVE: This article reviews the authors' understanding of the role of Class IA PI3K in the biology of human cancers and present discovery efforts to identify and develop inhibitors of this class of lipid kinases. METHODS: Books,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Source

Identifiers

PMID: 18208370
DOI: 10.1517/14728222.12.2.223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery.PMID 18208370Read ↗

Advances in subunits of PI3K class I in cancer.Semantic proximity Read ↗

The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments.Semantic proximity Read ↗

Targeting PI3K family with small-molecule inhibitors in cancer therapy: current clinical status and future directionsSemantic proximity Read ↗

PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer TargetSemantic proximity Read ↗

Recent progess in phosphoinositide 3-kinases: oncogenic properties and prognostic and therapeutic implications.Semantic proximity Read ↗

Oncogenic PI3K and its role in cancer.Semantic proximity Read ↗

The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human CancerSemantic proximity Read ↗

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapySemantic proximity Read ↗

The emerging mechanisms of isoform-specific PI3K signalling.Semantic proximity Read ↗

Targeting PI3K in Cancer: Any Good News?Semantic proximity Read ↗

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.Semantic proximity Read ↗

Class I PI3K in oncogenic cellular transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.