Advances in subunits of PI3K class I in cancer.

doi:10.1097/PAT.0000000000000066

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Article

Advances in subunits of PI3K class I in cancer.

Pathology - 1 Apr 2014

Cui Wenli, Cai Ying, Zhou Xiaoyan

Abstract excerpt

Phosphatidylinositol 3-kinases (PI3Ks) include members of a unique and conserved family of intracellular lipid kinases that phosphorylate the 3-hydroxyl group of phosphatidylinositols and phosphoinositides. The resultant activation of many intracellular signalling pathways regulates various biological functions such as cell metabolism, survival, growth, proliferation, polarity, and apoptosis. PI3Ks are classified...

Topics

Apoptosis
Enzyme Inhibitors
Humans
Mutation
Neoplasms
Phosphatidylinositol 3-Kinases
Phosphoinositide-3 Kinase Inhibitors
Protein Isoforms
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 24614719
DOI: 10.1097/PAT.0000000000000066

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