Article
A novel small-molecule inhibitor of the chromosome segregation process in yeast.
Molecular genetics and genomics : MGG - 1 May 2004
Yoon H-J
Abstract excerpt
The centromeres of budding yeasts contain specific and essential DNA sequences, in contrast to the regional heterochromatic centromeres found in higher organisms. Small molecules that perturb centromere function in budding yeast could be valuable candidates for identifying yeast-specific growth inhibitors. A combination of two in vivo assays, one based on transcription blockade of a reporter gene by the...
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