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Article

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity.

The Journal of biological chemistry - 4 Jun 2004

Lamkanfi Mohamed, Kalai Michael, Saelens Xavier, Declercq Wim, Vandenabeele Peter

Abstract excerpt

The proteolytic activity of caspases is involved in apoptosis and inflammation. In this regard, caspase-1 is required for pro-interleukin (IL)-1beta and pro-IL-18 maturation. We report here on a novel function of caspase-1 as an activator of nuclear factor of the kappa-enhancer in B-cells (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK). This function is not shared by the murine caspase-1 homologues...

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Source

Identifiers

PMID: 15039421
DOI: 10.1074/jbc.M400985200

Genes

TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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