Article
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.
PloS one - 1 Jan 2015
Yu Jong W, Hoffman Sandy, Beal Allison M, Dykon Angela, Ringenberg Michael A, Hughes Anna C, Dare Lauren, Anderson Amber D, Finger Joshua, Kasparcova Viera, Rickard David, Berger Scott B, Ramanjulu Joshi, Emery John G, Gough Peter J, Bertin John, Foley Kevin P
Abstract excerpt
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through recruitment of ubiquitin ligases, and as a protease to cleave and inactivate downstream inhibitory signaling proteins. However, our understanding of the relative importance of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.