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Article

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2014

Heymann Michael C, Winkler Stefan, Luksch Hella, Flecks Silvana, Franke Marcus, Ruß Susanne, Ozen Seza, Yilmaz Engin, Klein Christoph, Kallinich Tilmann, Lindemann Dirk, Brenner Sebastian, Ganser Gerd, Roesler Joachim, Rösen-Wolff Angela, Hofmann Sigrun R

Abstract excerpt

The proinflammatory enzyme caspase-1 plays an important role in the innate immune system and is involved in a variety of inflammatory conditions. Rare naturally occurring human variants of the caspase-1 gene (CASP1) lead to different protein expression and structure and to decreased or absent enzymatic activity. Paradoxically, a significant number of patients with such variants suffer from febrile episodes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24706726
DOI: 10.4049/jimmunol.1203524

Genes

CASP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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