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Article

Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice.

Journal of biological rhythms - 1 Apr 2004

Butler Matthew Preston, Honma Sato, Fukumoto Tatsuya, Kawamoto Takeshi, Fujimoto Katsumi, Noshiro Mitsuhide, Kato Yukio, Honma Ken-ichi

Abstract excerpt

DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock. The genes Dec1 and Dec2 are expressed rhythmically in the rat suprachiasmatic nuclei, and Dec1 expression is stimulated by light in a time-dependent manner with the kinetics of an immediate early gene. DEC1 and DEC2 can inhibit CLOCK:BMAL1 transactivation of the...

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Source

Identifiers

PMID: 15038852
DOI: 10.1177/0748730403262870

Genes

BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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