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Article

Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice.

Journal of biological rhythms - 1 Oct 2005

Noshiro Mitsuhide, Furukawa Masae, Honma Sato, Kawamoto Takeshi, Hamada Taizo, Honma Ken-ichi, Kato Yukio

Abstract excerpt

DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data on the expression patterns of mRNA for Dec1, Dec2, Per2, Dbp, and Npas2 in various tissues of...

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Source

Identifiers

PMID: 16267380
DOI: 10.1177/0748730405280195

Genes

CLOCK
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice.PMID 16267380Read ↗

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Dicer Expression Exhibits a Tissue-Specific Diurnal Pattern That Is Lost during Aging and in DiabetesSemantic proximity Read ↗

Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.Semantic proximity Read ↗

The mPer2 gene encodes a functional component of the mammalian circadian clock.Semantic proximity Read ↗

Daily Expression of mRNAs for the Mammalian Clock Genes Per2 and Clock in Mouse Suprachiasmatic Nuclei and Liver and Human Peripheral Blood Mononuclear CellsSemantic proximity Read ↗

DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.Semantic proximity Read ↗

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