Article
Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei.
Genomics - 15 Apr 1999
Steeves T D, King D P, Zhao Y, Sangoram A M, Du F, Bowcock A M, Moore R Y, Takahashi J S
Abstract excerpt
The Clock gene is an essential regulator of circadian rhythms. It encodes a member of the basic helix-loop-helix/PER-ARNT-SIM family of transcription factors known to play a central role in the control of diverse cellular events. Previously we described the functional identification and molecular isolation of the Clock gene in the mouse, its interaction with the BMAL1 protein, and the role of this complex as a...
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