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Article

Basic helix‐loop‐helix transcription factor DEC1 negatively regulates cyclin D1

18 Feb 2011

Abstract excerpt

DEC1 (also known as Stra13/Bhlhb2/Sharp2) and DEC2 (also known as Bhlhb3/Sharp1) are two paralogous basic helix-loop-helix (bHLH) transcriptional regulators which exhibit a robust circadian gene expression pattern in the suprachiasmatic nucleus (SCN) and in peripheral organs. DEC1 has been suggested to play key roles in mammalian cell differentiation, the cell cycle and circadian regulation, hypoxia response, and...

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PMID: 21506129
DOI: 10.1002/path.2878

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