Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54.

RNA (New York, N.Y.) - 1 Apr 2004

Yin Jiaming, Yang Ching-Hui, Zwieb Christian

Abstract excerpt

Signal recognition particle (SRP) guides secretory proteins to biological membranes in all organisms. Assembly of the large domain of mammalian SRP requires binding of SRP19 prior to the binding of protein SRP54 to SRP RNA. The crystal structure of the ternary complex reveals the parallel arrangement of RNA helices 6 and 8, a bridging of the helices via a hydrogen bonded A149-A201 pair and protein SRP19, and two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methanococcus

Share to Mutation

Share to Nucleic Acid Conformation

Share to Protein Binding

Share to Signal Recognition Particle

Source

Open in PubMed Open full text

Identifiers

PMID: 15037766
DOI: 10.1261/rna.5232404
PMCID: PMC1370547

Genes

SRP19
SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54.PMID 15037766Read ↗

Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control.Semantic proximity Read ↗

Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA.Semantic proximity Read ↗

Site-directed mutagenesis of signal-recognition particle RNA. Identification of the nucleotides in helix 8 required for interaction with protein SRP19.Semantic proximity Read ↗

Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle.Semantic proximity Read ↗

Interaction of protein SRP19 with signal recognition particle RNA lacking individual RNA-helices.Semantic proximity Read ↗

Evolutionary conserved nucleotides within the E.coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo.Semantic proximity Read ↗

Molecular evolution of SRP cycle components: functional implications.Semantic proximity Read ↗

A basic region neighboring the lysine-rich C-terminus of protein SRP19 is required for binding to signal recognition particle RNA.Semantic proximity Read ↗

The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation.Semantic proximity Read ↗

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain.Semantic proximity Read ↗

Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling.Semantic proximity Read ↗

Saccharomyces SRP RNA secondary structures: a conserved S-domain and extended Alu-domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.