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Article

Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling.

Journal of molecular biology - 6 Oct 2006

Gagnon Keith T, Zhang Xinxin, Agris Paul F, Maxwell E Stuart

Abstract excerpt

Archaeal dual-guide box C/D small nucleolar RNA-like RNAs (sRNAs) bind three core proteins in sequential order at both terminal box C/D and internal C'/D' motifs to assemble two ribonuclear protein (RNP) complexes active in guiding nucleotide methylation. Experiments have investigated the process of box C/D sRNP assembly and the resultant changes in sRNA structure or "remodeling" as a consequence of sRNP core...

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PMID: 16949610
DOI: 10.1016/j.jmb.2006.07.091

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