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Article

Targeted therapies in gastrointestinal stromal tumors.

Seminars in diagnostic pathology - 1 Nov 2008

Antonescu Cristina R

Abstract excerpt

The discovery of constitutive KIT activation as the central mechanism of gastrointestinal stromal tumor (GIST) pathogenesis suggested that inhibiting or blocking KIT signaling might be the milestone in the targeted therapy of GISTs. Indeed, imatinib mesylate inhibits KIT kinase activity and represents the front-line drug for the treatment of unresectable and metastatic GISTs. Despite a high rate of response in...

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Identifiers

PMID: 19013895
DOI: 10.1053/j.semdp.2008.08.004

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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