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Article

A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations.

Human heredity - 1 Jan 2003

van den Oord Edwin J C G, Sullivan Patrick F

Abstract excerpt

OBJECTIVES: To develop a method for designing studies to find disease mutations that can achieve a set of goals with respect to proportions of false and true discoveries with the minimum amount of genotyping. METHODS: Derivation of an analytical framework supplemented with simulation techniques. The approach is illustrated for a fine mapping study and a whole-genome linkage disequilibrium scan. RESULTS: The use...

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PMID: 15031620
DOI: 10.1159/000076393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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