Article
Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: sample size and power calculations.
Annals of human genetics - 1 May 2006
Hanson R L, Looker H C, Ma L, Muller Y L, Baier L J, Knowler W C
Abstract excerpt
Association (e.g. case-control) studies are often used to finely map loci identified by linkage analysis. We investigated the influence of various parameters on power and sample size requirements for such a study. Calculations were performed for various values of a high-risk functional allele (fA), frequency of a marker allele associated with the high risk allele (f1), degree of linkage disquilibrium between...
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