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Article

Quantifying the underestimation of relative risks from genome-wide association studies.

PLoS genetics - 1 Mar 2011

Spencer Chris, Hechter Eliana, Vukcevic Damjan, Donnelly Peter

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of associated loci across many common diseases. Most risk variants identified by GWAS will merely be tags for as-yet-unknown causal variants. It is therefore possible that identification of the causal variant, by fine mapping, will identify alleles with larger effects on genetic risk than those currently estimated from GWAS replication studies. We...

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PMID: 21437273
DOI: 10.1371/journal.pgen.1001337
PMCID: PMC3060077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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