Article
The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice.
Sleep - 1 Apr 2014
Zhou Lili, Bryant Camron D, Loudon Andrew, Palmer Abraham A, Vitaterna Martha Hotz, Turek Fred W
Abstract excerpt
STUDY OBJECTIVES: Efforts to identify the genetic basis of mammalian sleep have included quantitative trait locus (QTL) mapping and gene targeting of known core circadian clock genes. We combined three different genetic approaches to identify and test a positional candidate sleep gene - the circadian gene casein kinase 1 epsilon (Csnk1e), which is located in a QTL we identified for rapid eye movement (REM) sleep...
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