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Article

Mechanism of action of benzodiazepines on GABAA receptors.

British journal of pharmacology - 1 Aug 2006

Campo-Soria Claudia, Chang Yongchang, Weiss David S

Abstract excerpt

Wild-type and mutant alpha1beta2gamma2 GABA(A) receptors were expressed in Xenopus laevis oocytes and examined using the two-electrode voltage clamp. Dose-response relationships for GABA were compared in the absence and presence of 1 microM diazepam (DZP) or methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM). The dose-current relationships yielded EC(50)'s (concentration for half-maximal activation)...

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Identifiers

PMID: 16783415
DOI: 10.1038/sj.bjp.0706796
PMCID: PMC1751932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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