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Article

Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.

Nature neuroscience - 1 Apr 2003

Hosie Alastair M, Dunne Emma L, Harvey Robert J, Smart Trevor G

Abstract excerpt

Zinc ions are concentrated in the central nervous system and regulate GABA(A) receptors, which are pivotal mediators of inhibitory synaptic neurotransmission. Zinc ions inhibit GABA(A) receptor function by an allosteric mechanism that is critically dependent on the receptor subunit composition: alphabeta subunit combinations show the highest sensitivity, and alphabetagamma isoforms are the least sensitive. Here...

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PMID: 12640458
DOI: 10.1038/nn1030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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