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Article

Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABA(A) receptor through different channel property.

Acta physiologica (Oxford, England) - 1 Jan 2000

Wang M-D, Rahman M, Zhu D, Bäckström T

Abstract excerpt

AIMS: We compared the antagonistic effects of state-dependent gamma-aminobutyric acid A (GABA(A)) receptor blockers picrotoxin, Zn(2+) and pregnenolone sulphate (PS) on GABA- and pentobarbital-activated currents in recombinant rat GABA(A) receptors in Xenopus oocytes. METHODS: Experiments were performed with wild type rat alpha1 beta2 gamma2L and alpha1beta2 receptors, mutants alpha1V256S beta2 gamma2L and...

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PMID: 17054655
DOI: 10.1111/j.1748-1716.2006.01617.x

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