Article

Novel target identification & characterisation of key cell motility regulators in lung cancer metastasis

2014-01-01

Abstract excerpt

Lung cancer is the most common cancer killer worldwide. One of the major reasons for failing to cure this malignancy is the high rate of metastasis. Hence, understanding the mechanisms by which these cells metastasise is required to improve patients' survival. Using the non-small cell lung cancer cell line A549 we optimised a 3D Invasion assay to enable a robotised high-throughput siRNA screen of large gene librar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b59447d5-13ec-5453-97ca-168d9d39dc1b
DOI: 10.25560/24741

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel target identification & characterisation of key cell motility regulators in lung cancer metastasisDOI 10.25560/24741Read

TLK1-MK5 axis drives prostate cancer cell motility and pathologic features of aggressivenessSemantic proximity Read

Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis.Semantic proximity Read

EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancerSemantic proximity Read

The TLK1-MK5 axis regulates motility, invasion, and metastasis of prostate cancer cellsSemantic proximity Read

PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.Semantic proximity Read

A High-Content, Multiplexed Screen in Human Breast Cancer Cells Identifies Profilin-1 Inducers with Anti-Migratory ActivitiesSemantic proximity Read

Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.Semantic proximity Read

CD155/PVR plays a key role in cell motility during tumor cell invasion and migrationSemantic proximity Read

Transfection microarrays for high-throughput phenotypic screening of genes involved in cell migration.Semantic proximity Read

Motility‐Related Proteins as Markers for Head and Neck Squamous Cell CancerSemantic proximity Read

LIM kinase‐2 targeting as a possible anti‐metastasis therapySemantic proximity Read

EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7Semantic proximity Read