Article

JS-K—a NO prodrug—inhibits migration, invasion, and bone metastasis of renal cell carcinoma through the NF-κB signaling pathway

2025-06-20

Abstract excerpt

<title>Abstract</title> Background O2-(2, 4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1, 2-diolate (JS-K)—a nitric oxide prodrug—inhibits the proliferation and migration of breast cancer, non-small cell lung cancer, and liver cancer cells. However, its mechanism of action in renal cell carcinoma (RCC) remains elusive. This study seeks to investigate the effect of JS-K on RCC migration,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adac8849-761d-5028-92bf-1acc378adb96
DOI: 10.21203/rs.3.rs-6460853/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

JS-K—a NO prodrug—inhibits migration, invasion, and bone metastasis of renal cell carcinoma through the NF-κB signaling pathwayDOI 10.21203/rs.3.rs-6460853/v1Read

Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and SnailSemantic proximity Read

Real-world efficacy and safety of belzutifan in patients with metastatic renal cell carcinoma: a multicenter retrospective study in JapanSemantic proximity Read

Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP.Semantic proximity Read

Upregulation of PNCK Promotes Metastasis and Mediates Angiogenesis Via NF-κB/VEGF Signaling Pathway in Nasopharyngeal CarcinomaSemantic proximity Read

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast CancerSemantic proximity Read

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cellsSemantic proximity Read

Gigantol, a Bibenzyl from Dendrobium draconis, Inhibits the Migratory Behavior of Non-Small Cell Lung Cancer CellsSemantic proximity Read

Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune VaucherSemantic proximity Read

iNOS-Selective Inhibitors For Cancer Prevention: Promise And ProgressSemantic proximity Read

Role of nitric oxide in tumour progression with special reference to a murine breast cancer modelSemantic proximity Read

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.Semantic proximity Read

Inhibitory Impact of the Amino Benzoic Derivative DAB-2-28 on the Process of Epithelial-Mesenchymal Transition in Human Breast Cancer CellsSemantic proximity Read