Article
Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme.
Cancer research - 1 Dec 1996
Maelandsmo G M, Hovig E, Skrede M, Engebraaten O, Flørenes V A, Myklebost O, Grigorian M, Lukanidin E, Scanlon K J, Fodstad O
Abstract excerpt
The putative role of the CAPL gene in enhancing the development of human cancer metastasis was examined by transfecting human high-expressing osteosarcoma cells with a hammerhead ribozyme directed against the gene transcript. The ability of the ribozyme to cleave target mRNA in intact cells was d...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.