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Article

Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB.

Molecular cancer research : MCR - 1 May 2010

Connolly Erin C, Van Doorslaer Koenraad, Rogler Leslie E, Rogler Charles E

Abstract excerpt

Metastasis is a multistep process that involves the deregulation of oncogenes and tumor suppressors beyond changes required for primary tumor formation. RHOB is known to have tumor suppressor activity, and its knockdown is associated with more aggressive tumors as well as changes in cell shape, m...

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20460403
DOI: 10.1158/1541-7786.MCR-09-0465

Genes

RHOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20460403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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