Article
A role for LIM kinase in cancer invasion.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Yoshioka Kiyoko, Foletta Victoria, Bernard Ora, Itoh Kazuyuki
Abstract excerpt
In this study, we show that LIM kinase 1 (LIMK1), a critical regulator of actin dynamics, plays a regulatory role in tumor cell invasion. We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. Overexpression of LIMK1 in MCF-7 and in MDA-MB-231 human breast cancer cell lines increased their motility, whereas...
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