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Article

Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.

Journal of cell science - 15 Sept 2011

Lanning Nathan J, Su Hsiao-Wen, Argetsinger Lawrence S, Carter-Su Christin

Abstract excerpt

The adaptor protein SH2B1β participates in regulation of the actin cytoskeleton during processes such as cell migration and differentiation. Here, we identify SH2B1β as a new focal adhesion protein. We provide evidence that SH2B1β is phosphorylated in response to phorbol 12-myristate 13-acetate (PMA)-induced protein kinase C (PKC) activation and show that PMA induces a rapid redistribution of SH2B1β out of focal...

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Source

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Identifiers

PMID: 21878491
DOI: 10.1242/jcs.081547
PMCID: PMC3172186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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