Article
c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1.
Angiogenesis - 1 Jun 2012
Anselmi Francesca, Orlandini Maurizio, Rocchigiani Marina, De Clemente Caterina, Salameh Ahmad, Lentucci Claudia, Oliviero Salvatore, Galvagni Federico
Abstract excerpt
Vascular Endothelial Growth Factor-A (VEGF-A) is a key molecule in normal and tumor angiogenesis. This study addresses the role of c-ABL as a novel downstream target of VEGF-A in primary Human Umbilical Vein Endothelial Cells (HUVEC). On the basis of immunoprecipitation experiments, in vitro kinase assay and RNA interference, we demonstrate that VEGF-A induces the c-ABL kinase activity through the VEGF...
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