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Article

Accelerated induction of bladder cancer in patched heterozygous mutant mice.

Cancer research - 15 Mar 2004

Hamed Sahar, LaRue Hélène, Hovington Hélène, Girard Johanne, Jeannotte Lucie, Latulippe Eva, Fradet Yves

Abstract excerpt

The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc(+/-) heterozygous mutant mice and their wild-type littermates to...

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Identifiers

PMID: 15026327
DOI: 10.1158/0008-5472.can-03-2031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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