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Article

Patched Knockout Mouse Models of Basal Cell Carcinoma

1 Jan 2012

Abstract excerpt

Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation...

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PMID: 23024864
DOI: 10.1155/2012/907543

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