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Article

Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts.

Carcinogenesis - 1 Jun 2009

Zibat Arne, Uhmann Anja, Nitzki Frauke, Wijgerde Mark, Frommhold Anke, Heller Tanja, Armstrong Victor, Wojnowski Leszek, Quintanilla-Martinez Leticia, Reifenberger Julia, Schulz-Schaeffer Walter, Hahn Heidi

Abstract excerpt

Mutations in Patched (PTCH) have been associated with tumors characteristic both for children [medulloblastoma (MB) and rhabdomyosarcoma (RMS)] and for elderly [basal cell carcinoma (BCC)]. The determinants of the variability in tumor onset and histology are unknown. We investigated the effects of the time-point and dosage of Ptch inactivation on tumor spectrum using conditional Ptch-knockout mice. Ptch...

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Source

Identifiers

PMID: 19321799
DOI: 10.1093/carcin/bgp068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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