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Article

Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC.

Oncogene - 27 Jan 2005

Barnes Elizabeth A, Heidtman Keely J, Donoghue Daniel J

Abstract excerpt

Mutations in the transmembrane receptor patched1 (ptc1) are responsible for the majority of basal cell carcinoma (BCC) cases. Many of these mutations, including ptc1-Q688X, result in premature truncation of the ptc1 protein. ptc1-Q688X has been identified in patients with both BCC and nevoid basal cell carcinoma syndrome, an inheritable disorder causing a predisposition to cancer susceptibility. Here we describe...

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Identifiers

PMID: 15592520
DOI: 10.1038/sj.onc.1208240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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