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Article

Unbalanced overexpression of the mutant allele in murine Patched mutants.

Carcinogenesis - 1 May 2002

Calzada-Wack Julia, Kappler Roland, Schnitzbauer Udo, Richter Thomas, Nathrath Michaela, Rosemann Michael, Wagner Stephan N, Hein Rüdiger, Hahn Heidi

Abstract excerpt

Inherited mutations of Patched (PTCH) in the nevoid basal cell carcinoma syndrome (NBCCS) lead to several developmental defects and contribute to tumor formation in a variety of tissues. PTCH mutations have been also identified in sporadic tumors associated with NBCCS including basal cell carcinoma (BCC) and medulloblastoma. Mice heterozygous for Ptch recapitulate the typical developmental symptoms of NBCCS and...

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Source

Identifiers

PMID: 12016144
DOI: 10.1093/carcin/23.5.727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unbalanced overexpression of the mutant allele in murine Patched mutants.PMID 12016144Read ↗

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