Article
Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function.
Angewandte Chemie (International ed. in English) - 22 Apr 2024
Bardhan Anirban, Brown Wes, Albright Savannah, Tsang Michael, Davidson Lance A, Deiters Alexander
Abstract excerpt
Conditionally controlled antisense oligonucleotides provide precise interrogation of gene function at different developmental stages in animal models. Only one example of small molecule-induced activation of antisense function exist. This has been restricted to cyclic caged morpholinos that, based on sequence, can have significant background activity in the absence of the trigger. Here, we provide a new approach...
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