Article
Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans.
RNA (New York, N.Y.) - 1 Oct 2008
Chan Shih-Peng, Ramaswamy Gopalakrishna, Choi Eun-Young, Slack Frank J
Abstract excerpt
Little is known about the protein complexes required for microRNA formation and function. Here we used native gel electrophoresis to identify miRNA ribonucleoprotein complexes (miRNPs) in Caenorhabditis elegans. Our data reveal multiple distinct miRNPs that assemble on the let-7 miRNA in vitro. The formation of these complexes is affected but not abolished by alg-1 or alg-2 null mutations. The largest complex...
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