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Predisposition to abacavir hypersensitivity conferred by <i>HLA-B</i> * <i>5701</i> and a haplotypic <i>Hsp70-Hom</i> variant

15 Mar 2004

Abstract excerpt

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. We have previously shown that the presence of HLA-B*5701 strongly predicts abacavir hypersensitivity and have identified a potential susceptibility locus within a 300-kb region between the MEGT1 and C4A6 loci in the central MHC. We now report the results of fine...

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PMID: 15024131
DOI: 10.1073/pnas.0307067101

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