Article
Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus.
Arthritis and rheumatism - 1 Mar 2004
Kilding Rachael, Iles Mark M, Timms Janine M, Worthington Jane, Wilson Anthony G
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) has an estimated genetic contribution of 30-50%, approximately one-third of which arises from the major histocompatibility complex on 6p21.3. Many studies have implicated alleles of DRB1 that encode a shared epitope. However, several recent studies have suggested that additional telomeric genetic influences may exist. In this study, we sought to investigate whether a separate...
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