Article
BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility.
The Journal of rheumatology - 1 May 2008
Quiñones-Lombraña Adolfo, Lopez-Soto Alejandro, Ballina-Garcia Francisco Javier, Alperi-López Mercedes, Queiro-Silva Ruben, Lopez-Vazquez Antonio, Lopez-Larrea Carlos, Gonzalez Segundo
Abstract excerpt
OBJECTIVE: To analyze whether the polymorphisms -22 (G/C) and -348 (C/T) of the BAT1 gene are associated with susceptibility to rheumatoid arthritis (RA). METHODS: One hundred fifty-six patients with RA and 154 controls were genotyped for HLA-DRB1 and the polymorphisms -22 and -348 of the BAT1 gene. RESULTS: HLA-DRB1*04 alleles were associated with RA susceptibility (33.9% vs 20.1%; pc = 0.04). Among these,...
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