Article
Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis.
American journal of human genetics - 1 Sept 2002
Jawaheer Damini, Li Wentian, Graham Robert R, Chen Wei, Damle Aarti, Xiao Xiangli, Monteiro Joanita, Khalili Houman, Lee Annette, Lundsten Robert, Begovich Ann, Bugawan Teodorica, Erlich Henry, Elder James T, Criswell Lindsey A, Seldin Michael F, Amos Christopher I, Behrens Timothy W, Gregersen Peter K
Abstract excerpt
Rheumatoid arthritis (RA) is an inflammatory disease with a complex genetic component. An association between RA and the human leukocyte antigen (HLA) complex has long been observed in many different populations, and most studies have focused on a direct role for the HLA-DRB1 "shared epitope" in disease susceptibility. We have performed an extensive haplotype analysis, using 54 markers distributed across the...
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