Article
Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population.
Genes and immunity - 1 Oct 2011
El-Gabalawy H S, Robinson D B, Daha N A, Oen K G, Smolik I, Elias B, Hart D, Bernstein C N, Sun Y, Lu Y, Houwing-Duistermaat J J, Siminovitch K A
Abstract excerpt
Most of the genetic risk for rheumatoid arthritis (RA) is conferred by 'shared epitope' (SE), encoding alleles of HLA-DRB1. Specific North American Native (NAN) populations have RA prevalence rates of 2-5%, representing some of the highest rates estimated worldwide. As many NAN populations also demonstrate a high background frequency of SE, we sought to determine whether other genetic factors contribute to...
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