Article
The genetic contribution to the pathogenesis of rheumatoid arthritis.
Current opinion in rheumatology - 1 May 1998
Reveille J D
Abstract excerpt
The association of HLA-DR4 or other HLA-DRB1 alleles excoding the shared (or rheumatoid) epitope has now been established in nearly every population. Similarly, the fact that the presence and gene dosage of HLA-DRB1 alleles affect the course and outcome of rheumatoid arthritis has likewise been seen in most (although not all) studies. Family studies are making it increasingly clear that other genes are involved...
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